How to Publish a Medical Manuscript in a High-Impact Journal
Categories Scientific Communication

How to Publish a Medical Manuscript in a High-Impact Journal?

There is nothing more satisfying than seeing your research being published and visible to the outside world. After all, scientific publications connote an ongoing progress in the medical domain, and being its part is everyone’s dream.

Medical publications are the means to let the readers know about the advances in the knowledge of human anatomy, physiology, and medicine. Therefore, the knowledge they provide must be accurate, valid, trustworthy, and clinically useful. In other words, medical journals must exist primarily for their readers; to inform and instruct them about the new advances in the medical field and not only advertise about one’s work.

However, to get your medical manuscript published in a high-impact journal, you need to have the basic knowledge of the principles of scientific research and publishing, which is the mainstay of this blog.

Let’s highlight the essential steps to follow in order to publish your medical manuscript in a high-impact medical journal.

I. Do a good research

What makes up a good medical research?

One which is based on some logical rationale, addresses a real problem, has a clear-cut goal, is carried out in a  systematic and unbiased manner, and is replicable, verifiable, and incremental in nature.

5 Quick Steps For Good Research Are:

A. Choose a good research unit with a good mentor
If you are new to the field of scientific research, you need a good mentor from high-impact units to guide you      through the pitfalls and scientific follies associated with the research study.

B. Formulate your research question

which must stem out from a clinically important disease having a significant burden on the society. Go through the previous works and literature on your research topic to know what has been done and what more you can do.

C. Articulate the goal of your research
The ultimate goal of any medical research is to provide verified and valid information about the advances in the    medical field that could be used for the benefit of the suffering humanity. Ensure that your research study will    be able to fulfill this goal. Furthermore, having a clear view of your goal keeps you focused and systematic in conducting your research.

D. Collaborate with national or international groups having expertise in the area of your research. Such studies are more valid and have a higher impact than the ones carried out at one centre.

E. Have a sound study design
Designing your research study, what volunteers you will choose, what age and sex, how will you measure the    results etc. must be clearly defined from the beginning. Choose healthy volunteers as the control group.            Involve  a statistician to calculate and analyse the results right from the start. A double-blind randomized        placebo-controlled parallel group trial design is the most sound.

II. Writing your medical manuscript

Writing a medical manuscript can be compared to writing a story of your research that has a beginning, middle, and an end with a “take home” message.
While writing your manuscript:

  • Use simple language with attention to grammar, punctuation, spelling, and linguistic style.
  • Include content that is relevant to the topic of your paper and provides value to the reader. Keep it plagiarism free.
  • Strictly adhere to the format and word count laid down for the scientific manuscripts: Title, Abstract, Methods, Results, Discussion, Acknowledgements, References, Tables, and Figures.
  • The title must be catchy, concise, and descriptive, highlighting the contents and the importance of your research study. It should neither be too long nor too short. Write down a few possible titles and shortlist the best one.
  • An abstract is a crisp introduction to the contents of your manuscript. Make it comprehensive and interesting by answering the questions like: What was done? Why did you do it? What did you find and how are these findings useful and important? And what is the “take home” message?
  • Proofread your document carefully or get it reviewed by a colleague for any careless and grammatical mistakes. If you have any queries about writing manuscript please contact our medical manuscript writing service experts.

III. Getting your manuscript published

Check the details of the editorial committee, scope, and remit of your target journal in advance to avoid the possibility of future rejection or conflicts with the editorial staff.

Submit your completed manuscript by writing a cover letter to the editor-in-chief that should:
• Address the editor-in-chief (EIC) by name.
• Highlight the novelty of your work, its importance and compatibility with the journal’s remit and scope.
• Contain previous reviews of your work if any.
• Carry an approval of the manuscript by all its authors and its non-publication by any other journal.

Never submit your manuscript to two journals simultaneously.
After submission, your manuscript will be scrutinized by the editorial assistant, EIC, and the associate editor before it is either rejected or passed on for external peer review.

Now, your manuscript may get rejected or receive a major or minor revision or get accepted.

In case it gets rejected, which is likely in cases of lack of novelty, poor study design, lack of a clear message, and confusing charts, figures or tables, do not react in a rage. Even if you receive a major or minor revision, acknowledge the comments and queries placed by the editorial staff with honesty. Do not view them as your critics, but your supporters and assure them about your capability to rectify the loopholes in the manuscript, even if it requires an additional work on your part. If this is not possible, consider submitting your manuscript to another journal after making the changes as per the previous editor’s reviews. If you disagree with their comments, state your opinion firmly but politely.

And if your manuscript gets accepted, you can celebrate your achievement. But complete few tasks beforehand like completing the copyright assignment, conflicts of interest disclosure forms, editing of the typeset version, and updating your bibliography section.

Your manuscript is now scheduled for “online first” publication and will be provided a digital object identifier (DOI) number, a character string that is used to uniquely identify an object such as an electronic manuscript.

If at any time you have questions about our medical manuscript writing service , don’t hesitate to reach out and ask us.

Good luck with your publication!

high fat diet diminish the neural activity
Categories Medical news

Localized Inflammation in the Brain Linked To Overeating and Weight Gain

Researchers from the University of California, San Francisco and University of Washington Medical Center have shown that consumption of a fat-rich diet increases the number of brain immune cells called microglia which triggers a local inflammation within the mediobasal hypothalamus (MBH) and causes an individual to eat more food, burn fewer calories, and gain more weight.

A series of experiments were conducted on two groups of mice. One group was fed a fat-rich diet for four weeks and the other with a healthier low-fat diet. Comparing the results, the group that was fed with fat-rich diet consumed more food, burnt fewer calories and exhibited substantial weight gain.

The researchers further gave the mice on a fatty diet an experimental drug called PLX5622 which depleted the number of microglia in the mice. These mice ate 15 percent less appetite and gained 20 percent less weight than untreated mice on the same diet.

The results were confirmed by giving microglial inflammation activating drug to the mice fed with healthy, low-fat diet. This resulted in the mice eating 33 percent more food, burning 12 percent less energy and 400 percent increase in weight gain.

“It can be confidently concluded that the inflammatory activation of microglia is sufficient to alter the regulation of energy balance in the hypothalamus, leading to overeating and weight gain,” said Joshua Thaler, associate professor of medicine at the UW Medicine Diabetes Institute and senior co-author of the study.

Pig to Human Transplants May Be Possible In Future
Categories Medical news

Pig to Human Transplants May Be Possible In Future

Using the genetic cut and paste tool, CRISPR, scientists have moved a step closer to the possibility of pig organ transplants in human beings.

Currently, many people die waiting for the organ transplant due to the dramatic shortage in the availability of compatible organs. Though animals like pigs could act as an unlimited source of such organs, immune incompatibilities and viruses incorporated into the pig genome, called porcine endogenous retroviruses (PERVs), make this transplantation least likely.

However, scientists at eGenesis, a bioengineering company in Cambridge, Massachusetts, have come up with a genetic tool, CRISPR-Cas 9, that cuts the genome at the target points to remove 62 PERVs in pig cells in culture. Injecting these cells into the pig egg cells generated baby pigs that didn’t show any trace of PERVs.
This doesn’t mean that pig organs have become compatible for transplantation in humans; scientists have to work further to change other elements in pig transplants and make them compatible with the human body. Still, the removal of DNA-based viruses in pig organs has raised the chances of their transplantation into human patients one day, a process known as xenotransplantation.

The researchers of the study hope to see the combination of CRISPR technology with anti-apoptosis treatment not only for xenoptransplantation, but for large-scale genome engineering in primary cells.

Vitamin B3 Supplementation During Pregnancy may Prevent Birth Defects in Newborn
Categories Medical news

Vitamin B3 Supplementation During Pregnancy may Prevent Birth Defects in Newborn

According to a study in Australia, supplementing the diet with Vitamin B3 during pregnancy may treat molecular deficiencies in women and prevent birth defects in the newborn.

Developmental geneticist Sally Dunwoodie, Victor Chang Cardiac Research Institute, Sydney, and her team have been studying the genes that influence fetal heart and bone development for over 12 years. They observed gene mutations that affect the production of nicotinamide adenine dinucleotide (NAD) in four families having babies with heart and bone defects. NAD is essential for energy storage and DNA synthesis in cells.

Further study on pregnant mice revealed the use of Vitamin B3 or niacin found in mouse chow for the production of NAD in their bodies. To observe the effects of Vitamin B3, researchers fed a niacin deficient diet to the pregnant mice and observed the pups that were born. Many pups died before birth and those that were born showed birth defects similar to that observed in the human babies.

Next, the researchers fed the pregnant mice with a diet of low-dose niacin and observed a decline in the birth defects of the pups. As the richness of niacin in the diet was increased, the health of the born pups showed improvement.

“Mark my words,” says Sally. “The ramifications of this research are huge. Though more human studies are needed to recommend B3 supplementation for pregnant women, the current research suggests it may help to prevent birth defects in the newborn and reduce the number of miscarriages around the world.”

FDA approves new drug to treat Hepatitis C
Categories Medical news

FDA approves new drug to treat Hepatitis C

Nearly 2.7 to 3.9 million Americans are suffering from Hepatitis C, a disease that progresses slowly over decades without showing any symptoms unless it causes severe damage to the liver. Without treatment, it can either result in death or liver failure or cancer requiring a liver transplant.

Till now, Hepatitis C was treated with a combination of shots and pills without an effective cure and side-effect of flu-like symptoms. This was followed by pill-only medicines by Gilead in 2013 that brought cure in 12 weeks for more than 90 percent of the patients. However, the cost of treatment was huge (approx. $94,500) and strained the country’s insurance and health schemes.

Considering the scenario, AbbVie Inc., North Chicago, Illinois, has come up with the drug Mavyret, that combines two drugs in one pill and has been approved by the Food and Drugs Administration (FDA) for the treatment of patients not improved by prior treatment or in adults without significant liver cirrhosis.
Testing has shown to cure 97.5% patients and 98% patients with severe kidney damage after eight and twelve weeks of treatment respectively.

Mavyret has been priced well below the other approved drugs. “For marketing purpose, the company will initially focus on getting the coverage approved by Medicare, Medicaid and the Veterans Administration”, said AbbVie spokesman Morry Smulevitz.

Mavyret is the latest drug that cures all six types of Hepatitis C as compared to the other drugs that treat only one or few types of Hepatitis C in certain stages of the disease.