Preclinical research - Cognibrain®

Jul 07 0

Arrive Guidelines for Preclinical Studies: Importance in Bioscience Research Reporting

Posted by Siva Raman

Introduction ARRIVE guidelines are important for good reporting of the research conducted on animals. There are various advantages to following ARRIVE guidelines. Following these guidelines will increase validity and transparency in research articles and will become the guiding light for further research. Need and Importance of Good Reporting In the present times, several journals are involved in publishing the latest researches on biosciences. To provide accurate information to the readers,

Jul 18 0

Flow Cytometry and its Role in Preclinical Studies

Posted by krishna kumar

Flow cytometry is a semi-quantitative technique in biotechnology used for cell counting, cell sorting, biomarker detection, and protein engineering. The technique is commonly used to monitor the immune response by measuring the frequency and functionality of different immune cells. The instrument used is known as flow cytometer. The cells stained with specific fluorochrome-conjugated antibodies are passed through the flow cytometer to analyse the frequency and other properties of the cells

Jul 06 0

Medical Device Development: Design Validation and Preclinical Research

Posted by krishna kumar

For medical device manufacturers, the preclinical testing of medical device development is most crucial. This is the stage in which they set the design of the product including its functionality and safety aspects and validate the selected materials. However, their major dilemmas are “When to plan the preclinical stage of the device development?” and “What aspects to consider?” So, here we answer these questions to help the medical device manufacturers in their preclinical research

Apr 25 0

Improving the Preclinical Study Reporting: The ARRIVE Guidelines

Posted by krishna kumar

The scientific communication industry has advanced leaps and bounds. However, things have changed little regarding the drug development process. Many researchers and scientists do not publish the negative findings of a preclinical study. All forms of research - preclinical, clinical, animal or human based, and with both positive and negative outcomes demand a reliable reporting. But, this doesn’t happen due to the absence of specific requirements/guidelines for reporting the research studie

Apr 13 0

How to Design a Preclinical Study that makes a Difference?

Posted by krishna kumar

Many preclinical studies are conducted and thousands of research papers are published every year. However, these publications fail to provide clear information on how the study was designed, conducted, and analysed. They lack the standards of scientific rigour and transparency in their reports. As a result, they lose their value in informing future scientific studies, designing drugs and making policy decisions. In such a scenario, you can be a role model and increase the potential of your

Apr 03 0

Common Barriers to Preclinical Studies and How to Overcome Them

Posted by krishna kumar

The scientists, physicians, and academicians who investigate the preclinical studies are busy individuals. They do not involve themselves in one study at a time but in multiple studies. Plus, they have their own clinical duties and responsibilities. This gives them little time to stay engaged in any of the preclinical studies. Thus, a preclinical research study suffers from a poor engagement by its investigators and its progress gets delayed. It can further impact the quality of the research res

Mar 14 0

Why Are Clinical Trials Necessary?

Posted by krishna kumar

Clinical research is as an experiment conducted on human beings to evaluate the safety & efficacy of new drugs, medical devices, new drug delivery systems etc. Several thousands of new drugs enter the market each year and unless they are tested in humans, we cannot accurately predict their effect on them. Thus, clinical trials become necessary. But, many people in India consider preclinical research as a curse and state that “Human Beings are treated as Guinea Pigs.” They are concerne

Mar 02 0

The Types of Studies in Preclinical Trials

Posted by krishna kumar

Preclinical trials, also known as non-clinical trials are the laboratory tests of a new drug, device or medical treatment on animal subjects. The main aim of preclinical studies is to see whether the drug or the treatment really works and whether it is safe to test on humans. Thus, the main goal of a preclinical research is to collect sufficient data and establish the safety profile of the drug or the treatment under question. And to fulfill this objective, various types of studies are carrie

Jan 22 0

5 Steps of Drug Development Process

Posted by krishna kumar

It takes nearly 12 years for a new drug to reach the patient from a research lab. This time period is spent to discover and develop the drug to make it fit for human consumption. To know how the drugs are developed before you can buy them from the store; take a look at the steps of drug development process involved in preclinical studies: HANDPICKED RELATED CONTENT: Are There Any Alternatives to Animal Testing in Preclinical Research? An Insight into Good Laboratory Practices for

Jan 19 0

Why the Pig is a Good Preclinical Model over Rodents for Research on Wound Healing?

Posted by krishna kumar

All preclinical studies are designed to know the effectiveness of a particular treatment in human beings. With advancements in Science, in vitro studies have gained recognition to provide relevant information in research. But, animal testing continue to prove their utility in preclinical research studies. Rodents are used in maximum studies, but for wound healing research, pigs are considered fit as preclinical models. This is so because rodents differ from humans in a number of anatomical

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