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All Posts in Category: Formulation Research

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Are Excipients used in Formulation Development Inert?

Are Excipients used in Formulation Development Inert?

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We add spices to a meal for enhancing its taste and acceptance. Similarly, we have to add many additives in drug formulations to enhance their performance. These additives, also called excipients play a major role in the development of drug formulations. They hold together the components of the active drug substance and make it stable, palatable, and acceptable to the patients. However, we often define the excipients as inert or inactive compounds which are added to the drug formulations. B
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What are the Secrets to Successful Drug Formulations?

What are the Secrets to Successful Drug Formulations?

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Drug formulation is a process where various chemical substances are combined with the active drug to form a final medicinal product that is easy and safe for human consumption. It plays a pivotal role in the success of any pharmaceutical development program. From the early stage preclinical studies to the late-stage clinical trials, formulation chemistry is used to design a safe and effective product. However, formulation chemistry is often overlooked during the early stages of drug develo
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Role of Excipients in Formulation Development

Role of Excipients in Formulation Development

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An excipient, also known as the pharmaceutical inactive ingredient, is a substance that is formulated along with the active drug substance during the manufacture of the medicinal product. It is intended to act as a carrier of the active drug substance and contribute to its stability, pharmaceutical profile, appearance, and patient acceptability. In other words, it’s rare to find a drug containing only the active drug substance. The various functions performed by the excipient in drug for
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What you Must Know Before Starting a Preformulation Study

What you Must Know Before Starting a Preformulation Study?

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No doubt, preformulation studies investigate the physical, chemical, and mechanical properties of the drug substance and provide important information to formulate a safe and effective dosage form of the drug. But, do the formulation scientists immediately jump to carry out the preformulation studies of the drug substance the moment it’s discovered? NO! Certain preliminary and essential steps form an integral part of the drug development process; even before the preformulation studies.
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Right Formulation for Topical Drug Development

How Important is the Right Formulation for Topical Drug Development?

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Topical formulations are becoming increasingly popular in the pharmaceutical industry. Not only have they allowed the delivery of the drug substance to a specific site, but they also avoid fluctuations in drug levels, inter and intra-patient variations, and improve the patient’s compliance with the treatment. In a topical formulation, the skin acts as a perfect medium for the delivery of the drugs having both local and systemic effects, but also acts a mechanical barrier for the penetration of
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What does a Formulation Scientist do

What does a Formulation Scientist do?

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Ever wondered what makes up that tablet you gobble down during a headache? It's not only the active drug but colourants, flavours, binders, and many other ingredients that make up the final product. Some increase the therapeutic properties of the drug, while others aid in the manufacturing process. But, how to determine which products to combine and in what ratio? That's where a formulation scientist comes in. The typical role of a formulation scientist comprise of: Design multivariate
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Drug Formulation Forms

What are the Different Forms of Drug Formulation?

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Pharmaceutical formulation is the process of combining various chemical substances with the active drug to form a final medicinal product, which is called a drug mixture or drug formulation. A drug formulation can be given to the patient in various forms like solid, semisolid or liquid.  The type of the formulation given depends upon the patient's age, sex, and health condition and is specific for particular routes of administration. Here we give a brief overview of the different forms of
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What are the Parameters of Research in Preformulation Studies

What are the Parameters of Research in Preformulation Studies?

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Preformulation study; the term is frequently heard in a pharmaceutical industry. But, what is it exactly? A Preformulation study is an investigation of the physical, chemical, and mechanical properties of a drug substance to develop a safe, effective, and stable dosage form. Thus, it forms an integral part of the drug development process. Just like any research study is carried out to accomplish a particular goal, the main objective of Preformulation studies is to accomplish the following:
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