ARRIVE guidelines are important for good reporting of the research conducted on animals. There are various advantages to following ARRIVE guidelines. Following these guidelines will increase validity and transparency in research articles and will become the guiding light for further research.
Need and Importance of Good Reporting
In the present times, several journals are involved in publishing the latest researches on biosciences. To provide accurate information to the readers,
Flow cytometry is a semi-quantitative technique in biotechnology used for cell counting, cell sorting, biomarker detection, and protein engineering. The technique is commonly used to monitor the immune response by measuring the frequency and functionality of different immune cells. The instrument used is known as flow cytometer. The cells stained with specific fluorochrome-conjugated antibodies are passed through the flow cytometer to analyse the frequency and other properties of the cells
The scientific communication industry has advanced leaps and bounds. However, things have changed little regarding the drug development process. Many researchers and scientists do not publish the negative findings of a preclinical study.
All forms of research - preclinical, clinical, animal or human based, and with both positive and negative outcomes demand a reliable reporting. But, this doesn’t happen due to the absence of specific requirements/guidelines for reporting the research studie
Many preclinical studies are conducted and thousands of research papers are published every year. However, these publications fail to provide clear information on how the study was designed, conducted, and analysed. They lack the standards of scientific rigour and transparency in their reports. As a result, they lose their value in informing future scientific studies, designing drugs and making policy decisions.
In such a scenario, you can be a role model and increase the potential of your
The scientists, physicians, and academicians who investigate the preclinical studies are busy individuals. They do not involve themselves in one study at a time but in multiple studies. Plus, they have their own clinical duties and responsibilities. This gives them little time to stay engaged in any of the preclinical studies. Thus, a preclinical research study suffers from a poor engagement by its investigators and its progress gets delayed. It can further impact the quality of the research res
Preclinical trials, also known as non-clinical trials are the laboratory tests of a new drug, device or medical treatment on animal subjects. The main aim of preclinical studies is to see whether the drug or the treatment really works and whether it is safe to test on humans.
Thus, the main goal of a preclinical research is to collect sufficient data and establish the safety profile of the drug or the treatment under question. And to fulfill this objective, various types of studies are carrie
It takes nearly 12 years for a new drug to reach the patient from a research lab. This time period is spent to discover and develop the drug to make it fit for human consumption. To know how the drugs are developed before you can buy them from the store; take a look at the steps of drug development process involved in preclinical studies:
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All preclinical studies are designed to know the effectiveness of a particular treatment in human beings. With advancements in Science, in vitro studies have gained recognition to provide relevant information in research.
But, animal testing continue to prove their utility in preclinical research studies. Rodents are used in maximum studies, but for wound healing research, pigs are considered fit as preclinical models.
This is so because rodents differ from humans in a number of anatomical
The number of animals used in preclinical studies is continuously increasing. Each year millions of experimental animals across the world are sacrificed in the name of scientific research.
The pain, distress and death experienced by the animals during scientific experiments have been an issue of debate since long. Besides the major concern of ethics, there are few more disadvantages of using animals for scientific experiments, like requirement of skilled manpower, time consuming protocols, an
Preclinical research studies form an important step in the process of drug development. It is the method of collecting adequate data that helps the researchers to decide whether it is safe for you to take a particular drug or not by conducting thorough studies on animals or plant specimens.
But knowing the safety profile of the drug the only benefit or outcome of a preclinical studies?
A preclinical studies conducted to know the efficacy of a new drug or medical device a