Hypertension in Midlife of woman may leads to dementia
Categories Medical news

High Blood Pressure in Their 40s May Risk Women to Develop Dementia Later

Women who develop high blood pressure in their 40s may be more likely to develop dementia in later life, according to the study published in Neurology®, the medical journal of the American Academy of Neurology.

“High blood pressure in midlife is a known risk for dementia in later life, but this study will help to understand how and when this association starts and its gender differences,” said the study author Rachel A. Whitmer, PhD, Kaiser Permanente Division of Research in Oakland, Calif.

The study involved 7,238 people who were a part of the Kaiser Permanente Northern California health care system. Their blood pressure and other vitals were examined from the year 1964-1973. About 5, 646 people were again evaluated in the year 1996 and followed for 15 years to see who developed dementia. Nearly, 532 people were diagnosed with dementia.

The study revealed a 65-percent increased risk of dementia for women who developed high blood pressure in their 40s, irrespective of the other risk factors like smoking, diabetes, and body mass index.

“Though high blood pressure was more common in men, no evidence was found for an increased risk of dementia in them. More studies are needed to identify the possible sex-specific pathways for accelerated brain ageing through high blood pressure” said Whitmer.

However, the results of the study can’t be generalized to today’s population owing to the wide use and effectiveness of drugs to control high blood pressure.

Obese Woman May Affects Future Generation at Metabolic Risk
Categories Medical news

Obese Woman May Affects Future Generation at Metabolic Risk

Eating healthy and nutritious food keeps us healthy. However, sedentary lifestyle and switching to processed and fast foods have made obesity a popularized condition. A current mouse study, lead by Kelle H. Moley, published online in the journal Cell Reports has come up with a novel finding that a mother’s obesity leads to later obesity and other metabolic abnormalities in upcoming generations. Women following a Western diet develop metabolic and genetic abnormalities even before pregnancy which are subsequently forwarded to future generations, thereby making them prone to obesity-related conditions like Type 2 diabetes and heart disease.

This finding is pertinent since more than two-thirds of reproductive-age women in the US are obese. In the study, mice were fed a diet consisting of 60% fat and 20% sugar, nearly similar to the Western diet, right from six weeks before conception until weaning. The upcoming offsprings were then fed a diet containing high-protein, low-fat and low-sugar. Upto third descendents, the offsprings developed insulin resistance and other metabolic problems regardless of healthy diet.

Authors also found abnormal mitochondria in muscle and skeletal tissue of the progeny mice showing that mother’s obesity and associated metabolic abnormalities are inherited by transmitting dysfunctional genes of mitochondria in the unfertilized egg through the female bloodline. The mitochondrial DNA holds its own set of genes and is inherited only from mothers, not fathers. Additionally, oocytes also hoist information to program mitochondrial dysfunction throughout the body. Human offsprings are more susceptible to the effects of maternal metabolic syndrome since children follow the diets of parents