Digital Sensors for Digestive Tract monitoring
Categories Medical news

Rhythmic Contractions of the Digestive Tract Can Now Be Measured with Flexible Sensors

Researchers at MIT and Brigham and Women’s Hospital have built a flexible sensor that adheres to the lining of the stomach or intestine and measures the rhythmic contractions of the digestive tract.

Such sensors can help doctors to diagnose digestive disorders that impair the motility of the digestive tract. Further, they can be used to measure the food intake in patients treated for obesity.

These flexible sensors are based on piezoelectric materials, which generate a current and voltage on mechanical deformation. Polymers with elasticity similar to that of human skin are also incorporated in the sensors so that they can conform to the skin and stretch when the skin stretches.

“Having flexibility makes it easier for a sensor to transit the human digestive tract and imparts significantly improved safety over rigid ingestible sensors,” says Giovanni Traverso, a research affiliate at MIT’s Koch Institute for Integrative Cancer Research, a gastroenterologist and biomedical engineer at Brigham and Women’s Hospital.

Traverso teamed with Canan Dagdeviren, an assistant professor in MIT’s Media Lab and the director of the Conformable Decoders research group to develop this flexible sensor that can be can be rolled up and placed in a capsule. The capsule gets dissolved after being swallowed.

The effectiveness of the sensors was tested in pigs, where they successfully adhered to the stomach lining after being delivered through an endoscope. These sensors transmitted information about how much voltage was generated that helped researchers to calculate the movements of the stomach wall. They could also distinguish when food or liquid was ingested.

“For the first time, we showed that a flexible, piezoelectric device can stay in the stomach up to two days without any electrical or mechanical degradation,” says Dagdeviren.

Writing a Medical Thesis Tips for Post-Graduate Students
Categories Scientific Communication

Writing a Medical Thesis: Tips for Post-Graduate Students

What is a medical thesis?

A medical thesis is the written work resulting from an original research in the field of Medicine, Nursing, Pharmacy, and other health and life sciences. It is submitted by the students in order to obtain a higher degree from the University.

However, keep this in mind! The purpose of submitting a medical thesis is not limited to the achievement of a doctoral or post-graduate degree. It is a medium to organize the scientific knowledge in a way to make further progress in the field.

That’s the reason why the experts in medical thesis writing stress on the importance of choosing the right topic for your thesis. You must be able to address a genuine problem or series of problems through your medical thesis. Choose a topic that aligns with your interest and where you can offer a fresh perspective through your research study.

Writing your medical thesis

After choosing the topic for your research study, collaborate with your supervisor to design your research study and its goal. Collect all the information and data pertaining to your research before proceeding with your clinical trials.

Now, you are ready with your research data and clinical findings. You just need to pen down your findings in your medical thesis.

That sounds easy, isn’t it?

In reality, it’s not so. But, you need not worry! Writing a medical thesis becomes easy and fun if you follow the given steps with competence:

1.Outline the structure of medical thesis

Prepare an outline of the thesis in accordance with the following sections:

  • Title
  • Introduction: Why did you start your study?
  • Methods Used
  • Results of the study
  • Discussion of results
  • Conclusion

List the major sections and chapters in each. Do a section at a time. Assemble all the figures and tables and organise them into a logical sequence.

2.Writing a title of the thesis

The title reflects the content of your thesis. For writing a perfect thesis title:

  1. Be concise and accurate. The title must neither be too long nor too short
  2. Avoid unnecessary words and phrases like “Observation of” or “A study of”
  3. Do not use abbreviations
  4. Avoid grammatical mistakes

3.Writing an Introduction

The purpose of writing an Introduction is to provide the reader with sufficient background information on the topic and help him understand and evaluate the results of the present study, without needing to refer to the previous publications on the topic.

  • Give this background information in brief in the first paragraph
  • Include the importance of the problem and what is unknown about it in the second paragraph
  • State the purpose, hypothesis, and objective of your study in the last paragraph

Do’s

Cite the research papers written on your research topic

Don’ts

  • Include unnecessary information other than the problem being examined
  • Include the research design, data or conclusion of your study
  • Cite well-known facts
  • Include information found in any textbook in the field

4.Writing the section of “Methods Used”

This section must be so written that the reader is able to repeat the study and validate its findings.

Write a detailed exposition about the participants in the study, what materials you used and how you analyzed the results

  • Give references but no description for established methods
  • Give a brief description and references for published but lesser known methods
  • Give detailed description of new methods citing the reasons for using them and any limitations if present

Don’ts

  • Include background information and results of the study
  • Refer to animals and patients as material
  • Use trade name of the drugs; instead, use their generic names
  • Use non-technical language for technical statistical terms

5.Writing your Results

Keep in mind the objective of your research while writing the “Results” section. The findings of the research can be documented in the form of:

  • Text
  • Tables
  • Figures
  • Illustrative graphs

Use text to summarize small amounts of data. Do not over-use tables, figures, and graphs in your paper. Moreover, do not repeat information presented in the table or figure in the text format. Text must be a summary or highlight of the information presented in tables or figures.

6.Discussing your Results

Good medical theses have a targeted discussion keeping it focused on the topic of the research. Include:

  • Statement of the principal findings. Make it clear to show that your thesis includes new information
  • Strengths and weaknesses of your study
  • Strengths and weaknesses in relation to the other studies
  • A take-home message from your study for clinicians and policymakers
  • Any questions that are left unanswered in your study to propose new research

How to conclude your medical thesis?

The conclusion of your research study must comprise of:

  1. The most important statement or remark from the observations
  2. Summary of new observations, interpretations, and insights from the present study
  3. How your study fills the knowledge gap in its respected field?
  4. The broader implications of your work
  5. How can your work be improved by future research?

However, avoid any statement that does not support your data.

With these tips, write your thesis like a pro and don’t let it delay your doctoral award!

Gastric Acid Restraint Drug affects the liver
Categories Medical news

Regular Gastric acid reflux Drugs Develop the Chronic Liver Disease

A study at University of California San Diego School of Medicine claims that suppression of stomach (gastric) acid by drugs alters specific gut bacteria, promoting liver injury and progression of three types of chronic liver disease.

Nearly 10% people use proton pump inhibitor (PPI) drug to relieve the symptoms of heartburn and acid reflux; this percentage being seven times higher for those suffering from a chronic liver disease.

The number of people suffering from chronic liver disease is rapidly rising in the Western countries due to rising prevalence of obesity and alcohol abuse. Moreover, PPIs like Prilosec, Nexium and Prevacid are commonly prescribed for individuals suffering from a chronic liver disease.

“But medications that suppress gastric acid secretion can change the composition of the gut microbiome promoting the growth of Enterococcus bacteria in the intestines and translocation to the liver, exacerbating inflammation and worsening chronic liver disease,” said senior author Bernd Schnabl, MD, associate professor of gastroenterology at UC San Diego School of Medicine.

The team researched on mice models that mimic alcoholic liver, non-alcoholic fatty liver (NAFLD), and steatohepatitis (NASH) diseases in humans. Those with gastric acid suppression were found to exhibit alterations in their gut microbiome with the specific growth of Enterococcus bacteria. These changes promoted liver inflammation and injury, increasing the progression of 3 types of chronic liver disease.

A cohort of 4,830 patients with the chronic alcoholic liver disease was also analyzed. PPI intake in these individuals increased their stool concentrations of Enterococcus and the risk of liver disease by 8.3%.

Thus, the researchers concluded an association between PPI use among people who abuse alcohol and risk of liver disease. “Though more clinical trials are necessary to definitively show this causality, this data should at least make people and clinicians think about reducing the use of PPIs in cases where they aren’t necessary. Alternatively, other methods for managing heartburn like losing weight and reducing intake of alcohol, caffeine, and fatty and spicy foods must be looked into”, said Schnabl.

Hypertension in Midlife of woman may leads to dementia
Categories Medical news

High Blood Pressure in Their 40s May Risk Women to Develop Dementia Later

Women who develop high blood pressure in their 40s may be more likely to develop dementia in later life, according to the study published in Neurology®, the medical journal of the American Academy of Neurology.

“High blood pressure in midlife is a known risk for dementia in later life, but this study will help to understand how and when this association starts and its gender differences,” said the study author Rachel A. Whitmer, PhD, Kaiser Permanente Division of Research in Oakland, Calif.

The study involved 7,238 people who were a part of the Kaiser Permanente Northern California health care system. Their blood pressure and other vitals were examined from the year 1964-1973. About 5, 646 people were again evaluated in the year 1996 and followed for 15 years to see who developed dementia. Nearly, 532 people were diagnosed with dementia.

The study revealed a 65-percent increased risk of dementia for women who developed high blood pressure in their 40s, irrespective of the other risk factors like smoking, diabetes, and body mass index.

“Though high blood pressure was more common in men, no evidence was found for an increased risk of dementia in them. More studies are needed to identify the possible sex-specific pathways for accelerated brain ageing through high blood pressure” said Whitmer.

However, the results of the study can’t be generalized to today’s population owing to the wide use and effectiveness of drugs to control high blood pressure.

Journal Impact Factor and Its Significance in Publishing Your Manuscript
Categories Scientific Communication

Journal Impact Factor and Its Significance in Publishing Your Manuscript

The Impact factor of a journal is one of the things authors consider while choosing the right journal for publishing their manuscript. But, what is this impact factor? Why is it considered important in selecting the target journal for publication?

Journal Impact factor is the number of times articles in the journal are cited in other publications for a particular year. For example, an impact factor of 3 indicates that each article in the journal was cited 3 times on average for a specific year.

So, the impact factor indicates the importance or the rank of a journal by calculating the times its articles are cited elsewhere. And an article that is cited many times represents a novel and interesting research, raising the impact factor of the journal.

Thus, impact factor forms an important tool for authors to evaluate the journals and submit their manuscript for publication.

However, there is a word of caution! Relying only on the impact factor is a mistake! You must also consider the topic of your research, your target audience, and the time-frame of publication that must match the journal guidelines you are ought to choose. Cognibrain medical manuscript writing service team help you to get your manuscript published in high impact medical journal.

Read the medical manuscript submission guidelines of your target journal beforehand!