Before submitting an IND application, the concerned drug must go through a comprehensive series of in-vitro and in-vivo toxicity testing to ensure maximum safety in clinical trials. Considering the ethical issues and the cost of in-vivo animal tests, the pharmaceutical industry now relies more on in-vitro methods for toxicity testing in the drug development phase.
Here, we answer the common questions regarding the in-vitro toxicity testing in drug development.
What is the right time to scree
Nowadays, the state governments lay more stress on prescription monitoring programs (PMPs). In such a scenario, the healthcare facilities have to test and prevent the abuse of commonly prescribed medicines.
However, they have one major dilemma. Whether to work with a drug confirmation or a toxicity testing labs?
Here, we tell you the difference between the two lab services and what each of them accomplishes.
A drug confirmation lab only verifies the drug usage
The facilities of this lab
Toxicity testing of pharmaceutical drugs forms a critical part of the risk-benefit assessment that balances the beneficial effects of the drug against the observed toxic and adverse effects. Despite advances in toxicity assessment, many drugs and chemicals are marketed without adequate toxicology data.
The increasing demand for nonclinical safety data in the early phase of drug development has posed the following challenges to toxicology testing, which must be adequately addressed:
Microsampling or the use of small amounts of sample tissue has become one of the hot topics for discussion in animal research. Many researchers are now discussing, investigating, and utilising the benefits of microsampling in toxicity testing.
Though there's a long way to go before microsampling becomes a routine in animal research, it still offers three benefits for toxicity testing:
1.It supports the 3Rs strategy
Due to the ethics related to the use of experimental animals, researchers ha