Toxicity testing of pharmaceutical drugs forms a critical part of the risk-benefit assessment that balances the beneficial effects of the drug against the observed toxic and adverse effects. Despite advances in toxicity assessment, many drugs and chemicals are marketed without adequate toxicology data.
The increasing demand for nonclinical safety data in the early phase of drug development has posed the following challenges to toxicology testing, which must be adequately addressed:
Microsampling or the use of small amounts of sample tissue has become one of the hot topics for discussion in animal research. Many researchers are now discussing, investigating, and utilising the benefits of microsampling in toxicity testing.
Though there's a long way to go before microsampling becomes a routine in animal research, it still offers three benefits for toxicity testing:
1.It supports the 3Rs strategy
Due to the ethics related to the use of experimental animals, researchers ha