No doubt, preformulation studies investigate the physical, chemical, and mechanical properties of the drug substance and provide important information to formulate a safe and effective dosage form of the drug.
But, do the formulation scientists immediately jump to carry out the preformulation studies of the drug substance the moment it’s discovered?
NO! Certain preliminary and essential steps form an integral part of the drug development process; even before the preformulation studies.
Topical formulations are becoming increasingly popular in the pharmaceutical industry. Not only have they allowed the delivery of the drug substance to a specific site, but they also avoid fluctuations in drug levels, inter and intra-patient variations, and improve the patient’s compliance with the treatment. In a topical formulation, the skin acts as a perfect medium for the delivery of the drugs having both local and systemic effects, but also acts a mechanical barrier for the penetration of
Ever wondered what makes up that tablet you gobble down during a headache?
It's not only the active drug but colourants, flavours, binders, and many other ingredients that make up the final product. Some increase the therapeutic properties of the drug, while others aid in the manufacturing process.
But, how to determine which products to combine and in what ratio?
That's where a formulation scientist comes in. The typical role of a formulation scientist comprise of:
Pharmaceutical formulation is the process of combining various chemical substances with the active drug to form a final medicinal product, which is called a drug mixture or drug formulation.
A drug formulation can be given to the patient in various forms like solid, semisolid or liquid. The type of the formulation given depends upon the patient's age, sex, and health condition and is specific for particular routes of administration.
Here we give a brief overview of the different forms of
Preformulation study; the term is frequently heard in a pharmaceutical industry. But, what is it exactly?
A Preformulation study is an investigation of the physical, chemical, and mechanical properties of a drug substance to develop a safe, effective, and stable dosage form. Thus, it forms an integral part of the drug development process.
Just like any research study is carried out to accomplish a particular goal, the main objective of Preformulation studies is to accomplish the following: