All preclinical studies are designed to know the effectiveness of a particular treatment in human beings. With advancements in Science, in vitro studies have gained recognition to provide relevant information in research.
But, animal testing continue to prove their utility in preclinical research studies. Rodents are used in maximum studies, but for wound healing research, pigs are considered fit as preclinical models.
This is so because rodents differ from humans in a number of anatomical and physiological ways. A rodent has dense hair and thin epidermis and dermis. On the other hand, pig and human beings have various similarities like:
- The skin of a pig is relatively hairless and structurally similar to the humans in terms of epidermal thickness, nature of the subcutaneous tissue, and pattern of cutaneous blood flow.
- The protein and lipid composition of the skin is same in pigs and humans.
- Pigs have a similar digestive physiology as humans, which enable the researchers to better investigate absorption and bioavailability of the drug.
- The liver and kidneys of the pigs resemble that of humans in anatomy and physiology to predict toxic effects with more accuracy.
Thus, pigs serve as the best preclinical models to study all drug delivery methods with human-like metabolic pathways and specificity, offering great advantages in wound healing research and beyond.