Unhealed wounds or majorly foot ulcer is a complicated condition for patients with type 2 diabetes which result in skin and tissue damage, and may finally leads to limb amputations. Presently there are no strong promising drugs that can treat chronic diabetic wounds and frequently it makes us to move to choose an option of surgical procedure. Diabetes is accompanied by a significant oxidative stress which may affect even blood vessels leading to vessel dysfunction known as diabetic angiopathy, one of the major reasons for delayed wound healing.
Considering the pathophysiology of diabetic wounds and diabetic angiopathy, researchers from Lomonosov Moscow State University conducted a preclinical study by targeting mitochondrial oxidative stress and the results were published in the journal of Oxidative Medicine and Cellular Longevity.
A senior researcher of study, Dr. Roman Zinovkin and his co-scientist said that, mitochondria targeted antioxidant SkQ1 has significantly improved the formation of epithelial tissue and granulation tissue showing the effective wound healing in diabetes mouse model. Besides this, restoration of distorted blood circulation by stimulation of vascularization shows the efficacy of SkQ1. Researchers continued their experiments on animal models and various cell cultures using immunological and histologic approaches, biochemical and molecular biological techniques.
From these experiments, scientists reported that SkQ1, a mitochondria targeted antioxidant, involves in all major steps of wound healing. This proves that reactive oxygen species produced by mitochondria have a major role in the pathogenesis of diabetic wounds.