Researchers from the University of California, San Francisco and University of Washington Medical Center have shown that consumption of a fat-rich diet increases the number of brain immune cells called microglia which triggers a local inflammation within the mediobasal hypothalamus (MBH) and causes an individual to eat more food, burn fewer calories, and gain more weight.
A series of experiments were conducted on two groups of mice. One group was fed a fat-rich diet for four weeks and the oth
Using the genetic cut and paste tool, CRISPR, scientists have moved a step closer to the possibility of pig organ transplants in human beings.
Currently, many people die waiting for the organ transplant due to the dramatic shortage in the availability of compatible organs. Though animals like pigs could act as an unlimited source of such organs, immune incompatibilities and viruses incorporated into the pig genome, called porcine endogenous retroviruses (PERVs), make this transplantation leas
According to a study in Australia, supplementing the diet with Vitamin B3 during pregnancy may treat molecular deficiencies in women and prevent birth defects in the newborn.
Developmental geneticist Sally Dunwoodie, Victor Chang Cardiac Research Institute, Sydney, and her team have been studying the genes that influence fetal heart and bone development for over 12 years. They observed gene mutations that affect the production of nicotinamide adenine dinucleotide (NAD) in four families having
Stents are metal or plastic tubes used in heart surgeries to open the narrowed coronary arteries and keep them so in future. However, bare metal stents cause restenosis or narrowing of the artery again after few years.
Second- and third-generation drug-eluting stents counteract this problem, but can lead to clumping of blood platelets and clot formation near the stent. To overcome this problem, a team of researchers led by Han-Mo Yang, Seoul National University Hospital conducted a study on a
Nearly 2.7 to 3.9 million Americans are suffering from Hepatitis C, a disease that progresses slowly over decades without showing any symptoms unless it causes severe damage to the liver. Without treatment, it can either result in death or liver failure or cancer requiring a liver transplant.
Till now, Hepatitis C was treated with a combination of shots and pills without an effective cure and side-effect of flu-like symptoms. This was followed by pill-only medicines by Gilead in 2013 that bro
Millions of people around the globe are taking heartburn and indigestion medications known as proton pump inhibitors (PPIs). These drugs neutralize the acid in the stomach and are widely prescribed by the physicians, with low doses available even without prescription.
However, Ziyad Al-Aly, an epidemiologist from the University of Washington and co-author of a study said, “We saw a small excess risk of dying that could be attributed to the PPI drug, and the risk increased the longer anyone ta
Nearly 5% of the population in the United States suffers from type 1 diabetes; an autoimmune disorder where the body’s immune system specifically fails to recognize pancreas’ insulin producing beta cells and mistakenly attacks them.
In the absence of sure shot treatment and the dearth of studies on immunotherapy, Dr Mohammad Alhadj Ali, Cardiff University School of Medicine, U.K., and Mark Peakman, professor of clinical immunology at King's College London, conducted a study on the possi
Colorectal cancer, the cancer that originates in the colon or rectum, is the third most common cancer diagnosed in the United States. A plethora of studies have established a link between consumption of high-fat diet and increased risk of colorectal cancer, but the mechanism of this association was till now obscure.
As reported in the journal, Stem Cell Reports, researchers from the Cleveland Clinic in Ohio have unfolded this mechanism. In a study that utilized mice as the models, researchers